ABSTRAK
Acrylamide is a chemical substance which derived from acrylonitrile, is the
material used in polyacrylamide production. Recent research has found acrylamide
is contained in some food, especially food is rich in carbohydrate and treated in high
temperature (more than 120°C). Due to its nature, acrylamide is classified as a
hazardous material to be contained in human’s food. The International Agency for
Research on Cancer (IARC) has classified acrylamide into group 2A (probably carcinogenic
for humans). Many methods that used to analyse the acrylamide in some
foods with sophisticated equipment, and in department of pharmacy FMIPA-UI
there were also develop the method with simple extraction and conventional HPLC.
Keywords : acrylamide, HPLC, carcinogenic.

ABSTRAK
For most reason for dry suspension is the drug changes from chemical degradation
or hydrolysis like ampicillin. The dry syrups that require mixing prior to administration
is solving the problem. These suspension are commersial, dry mixtures
that require the addition of water at the time of dispensing. Many antibiotics are
formulated as dry syrups and are intented for a pediatric patient population. There
are usually fewer suspending material in suspension dry syrup than in convensional
suspensions. The criteria for selecting inggredients are based both on suitable reconstitution
and on physical tipe of powder mixture desired. This research was carried
out the possibility of using phycical and chemical modification of cassava starch as
suspending material. First, pregelatinized cassava starch was made by heated the
cassava starch with added amount water. Secondly, phosphorylated by adding phosphorous
oxychloride for making cross-linked reaction and adding sodium monohydrogen
phosphate (Na2HPO4) for making substituted reaction respectively. Both
of the cassava starch phosphate derived was used in tree formulas dry syrup, as
comparative suspending material was Na Alginate. Then dry syrup was evaluated
accordance to Indonesian Farmacopea ed IV included sedimentation volume,
redispersion, viscosity, flowing properties, pH, and ampicillin content after seven
days. The result of evaluation were particle size 355-500 µm, flow rate 2,7-4,6 g/
det. Sedimention volume at temperature 27ºC during seven days for all formulas
were 0,8-1,0, and redispertion 3-5 times. The viskosity of the suspensions were
58,6-357,1 cps .Flowing properties of the liquids were plastis -plastis tixotropic,
pH 4,97-5,21, and ampicillin content between 93,12-99,00%.
Keywords: dry syrup, pregelatized cassava starch phosphate, ampicillin

ABSTRAK
Amoxiciilin is an antibiotic of penicillin. It has been used to treat bacterial
infections that caused by Gram negative bacteria and Gram positive bacteria. Most
of amoxicillin tablet has been sold with generic name and non generic name. This
research was proposed to compare quality and price of amoxicillin tablet 500 mg at
the drug store. Especially, for amoxicillin tablet 500 mg generic and non generic.
Determination of quality amoxicillin tablet could be showed from standard quality
of amoxicillin tablet was based at USP XXVI. Identification, dissolution and assay
were included standard quality of amoxicillin tablet. Identification test was performed
by TLC with mobile phase consist of methanol, chloroform, water and pyridine
(90:80:30:10). Assay of dissolution test was performed by HPLC with mobile
phase potassium dihydrogen phosphate buffer and acetonitrile (39:1). Assay of tablet
was performed by HPLC with mobile phase potassium dihydrogen phosphate buffer
and acetonitrile (96:4). The experiment was held to 15 brands of tablet which they
had consisted 3 brands of generic tablet and 12 brands of non generic tablet. The test
resulted that every brands of tablet fulfilled standard quality of amoxicillin tablet.
But in the test, there was variation of price, in ordinarily price of non generic tablet
was more expensive than generic tablet.
Key words : amoxicillin; generic; non generic; penicillin; standard quality.

ABSTRAK
A computer application named Farmakomatic 1.0 had been developed to calculate
pharmacokinetic parameters from plasma drug concentration data following intravenous
and oral administration with one and two compartment model using a
program application Microsoft® Visual Basic 6.0®. The application was evaluated
using two plasma drug concentration data. Calculation results of the Farmakomatic
1.0 and manual calculation using Microsoft® Excel 2003® were not different.
Key words : Computer application, Pharmacokinetic, Compartment model,
Pharmacokinetic parameter.

ABSTRAK
Red fruit (Pandanus conoideous Lam.) has been known by public as a medicine
for any kind of diseases, among of them is for cancer. To determine the carcinogenesis
inhibition effect of red fruit extract , we have examined the effect on 7,12-
dimethylbenz[a]anthrasene (DMBA)-induced rat lungs cancer model in female
Sprague-Dawley rats. The extract was tested at 0.21 ml/200 g bw; 0.43 ml/200 g bw
and 0.88 ml/ 200 g bw. The experiment was terminated at day 120. Lung histology
was used to evaluate carcinogenesis inhibition. The result showed that the extract at
0.21 ml/200g bw improved lung carcinogenesis inhibition than other dose.
Key words : red fruit extract, DMBA, lung cancer, Pandanus conoideus